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Set in America's Colonial period, John Ford's adventure tale follows Gilbert (Henry Fonda) and Lana Martin (Claudette Colbert) as they try to survive the rugged frontier. After their settlement is repeatedly attacked by Indians, the couple is taken in by a spinster (Edna May Oliver). Lana bears a son, while Gilbert heads off to fight the Indians and the British. He returns, wounded, to find his family once again under attack by the Indians.